|
KMID : 0371420221020010046
|
|
Annals of Surgical Treatment and Research
2022 Volume.102 No. 1 p.46 ~ p.54
|
|
|
Prognostic impact of serum soluble PD-1 and ADV score for living donor liver transplantation in patients with previously untreated hepatocellular carcinoma
|
|
Hwang Shin
Lee Kyung-Jin
Moon Deok-Bog
Song Gi-Won
Jung Dong-Hwan
Kim Yun-Kyu
Yang Hun-Ji
An Da-Eun
Lee Si-On
Lee Sung-Gyu
|
|
|
Abstract
|
|
|
Purpose: The programmed death protein 1 (PD-1) pathway is the critical mechanism in development of hepatocellular carcinoma (HCC). The present study analyzed the prognostic impact of pretransplant serum soluble PD-1 (sPD-1) concentration and α-FP?des-γ-carboxyprothrombin?tumor volume (ADV) score in patients with previously untreated HCC undergone liver transplantation (LT).
Methods: This retrospective single-center study enrolled 100 patients with HCC who underwent living donor LT from 2010 to 2016. Concentrations of sPD-1 were measured in stored serum samples.
Results: Receiver operating characteristic curve analysis of 2-year tumor recurrence resulted in an sPD-1 cutoff of 177.1 μg/mL, which was associated with higher rates of tumor recurrence (P = 0.022), but not with overall patient survival (P = 0.460). The derived cutoff for pretransplant ADV score was 5.4log, which was associated with higher tumor recurrence rate (P < 0.001) and lower overall patient survival rate (P < 0.001). Both sPD-1 of >177.1 μg/mL (hazard ratio [HR], 2.26; P = 0.020) and pretransplant ADV score of >5.4log (HR, 3.56; P < 0.001) were independent risk factors for posttransplant HCC recurrence. The combination of these 2 factors enabled the stratification of patients into 3 groups, with groups having 0, 1, and 2 risk factors differing significantly in the prognosis of tumor recurrence (P < 0.001) and overall patient survival (P = 0.006).
Conclusion: Both sPD-1 concentration and ADV score have prognostic impacts in patients who underwent LT for untreated HCCs. These factors, both individually and combined, can help in predicting posttransplant prognosis.
|
|
|
KEYWORD
|
|
|
Hepatocellular carcinoma, Immune checkpoint, Prognosis, Recurrence, Tumor biology
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
   
|